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KMID : 1094720070120020152
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Biotechnology and Bioprocess Engineering
2007 Volume.12 No. 2 p.152 ~ p.156
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Biodegradable molecularly imprinted polymers based on poly(ε-caprolactone)
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Lee Kyung-Soo
Kim Dae-Su
Kim Beom-Soo
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Abstract
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Novel biodegradable molecularly imprinted polymers (MIPs) based on poly(ε-caprolactone) (PCL) were prepared by combining two important properties required of ideal biomaterials, biodegradability (with biocompatibility) and molecular recognition properties. Acrylate or methacrylate end-capped PCL macromers were synthesized through the reaction of PCL diol or triol with acryloyl or methacryloyl chloride. The synthesis of acrylate or methacrylate end-capped macromers was confirmed using FT-IR and H NMR spectroscopic techniques. These macromers were used to prepare biodegradable crosslinked networks by photopolymerization with functional monomer (acrylic acid) and a model template (theophylline). The theophylline-imprinted polymer showed higher binding capacity for theophylline compared with non-imprinted polymer (NIP), and also showed selectivity for theophylline over caffeine (similar structure molecules). PCL-based MIP degraded 8% of the initial weight in 30 days in phosphate-buffered saline (PBS) solution (pH 7.4) and over 90% of the initial weight within 24 h in 1 N NaOH at 37°C.
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KEYWORD
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molecularly imprinted polymer, biodegradable, poly(ε-caprolactone)
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